Cystitis Research Center

- Doctor Information -

Letter from Dr. Fugazzotto to Pathologists and Labs
Synopsis Of Test Detail

Letter from Dr. Fugazzotto to Doctors

David J. Fugazzotto, M.D., FAA
Paul Fugazzotto, PhD, MSPH (Emeritus Member; Association of Public Health Laboratories)

MEMO

FROM: The Cystitis Research Center (CRC)
TO: Doctors of CRC participating patients

Dear Doctor,

As result of our researching the diagnosis of pelvic disorder in hundreds of participants, you have probably been aware of the CRC test validity in use of the same scientific principles universally employed by medical laboratories the world over in diagnosis of all other disease entities. We are certain we cannot possibly handle the load of the thousands who need this attention. We must, therefore, recruit the intervention of the entire medical lab industry. To that end we must ask that you approach medical hospital or other labs in your area, hence forth to accept these patients on the following basis:

You see the patient. We are sure from our experience that the history and symptoms relayed to you are convincing enough evidence that infection does in fact exist.
We have proven in processing more than 1900 victims that there is no need to pad patient expenses with inconclusive preliminary tests and procedures as a monetary excuse to prove the contrary. You know as a doctor, that only direct authentic culture for ETIOLOGIC AGENTS has been valid evidence of infection ---- not UA, colony counts of saprophytes, or other manipulations.
From here on, the following points are important: a proper specimen; taken according to the attached; the patient off antibiotics for 48+ hours.
The testing must follow pure culture technology, as employed in diagnostic components (as per CRC instructions), cultured in Trypticase Soy Broth.
The etiologic agent is a strain of Gram-positive cocci (staph/strep). From your experience with the CRC, you know these are the etiologic agents.
This intends to be an authentic program for which your local lab is fully equipped. They should contact the CRC for more information.

We see this as the only logical effective approach to eventual authentic management of the millions. We will not abandon the effort, but pledge to stand by for technical support. PLEASE TRY TO FORCE THE ISSUE WITH YOUR LOCAL LAB. They cannot disclaim their obligation to the health needs of the public.

Sincerely yours,
Paul Fugazzotto, PhD.

[Back to Top]

Synopsis Of Test Detail

Please be assured that at the CRC, assessing the patient's condition by lab procedure is not a "quickie" 15 minute to 24 hour guessing game. Testing of specimens consists of:

A purging procedure, for removal of urine wastes that interfere with emergence of invasive pathogens.
The purged residue is cultured in an all-purpose broth to grow out ALL the species of organisms present in the urine (contrary to the conventional test which is focused ONLY on fecal bacilli, by colony count).
Aliquots of the broth culture are transferred to differential media, scrutinized for presence of classically established pathogens (Gram positive coccus species, as separated from the contaminants) and identified.
The pure culture is tested for sensitivity to a panel of 12-15 antibiotics, and reported according to manufacturer's specifications for physicians evaluation and prescription.
Follow-up testing is done to determine need for antibiotic adjustment (done only by the CRC on research findings from tests on 8300 + specimens).
The CRC procedures (compared to the conventional tests, on about 22000 acute and chronic patients, including Interstitial Cystitis), has conclusively pointed to the Gram-positive coccus species as the etiologic Urinary Tract Infection/Interstitial Cystitis, Prostatitis agent, responding well to the specifically determined antibiotics, under periodic monitoring, by lab testing not readily evaluated in the doctor's office, without lab findings.
The CRC welcomes comments, questions, and discussion.

[Back to Top]